Children who were treated with oral immunotherapy for cows’ milk allergy showed long-term desensitisation seven years later. 2016

Link to article: Children who were treated with oral immunotherapy for cows’ milk allergy showed long-term desensitisation seven years later. Acta Paediatr. 2016 Feb;105(2):215-9.

Author information

  • 1Allergy Centre, Tampere University Hospital, Tampere, Finland.
  • 2Centre for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
  • 3Science Centre, Pirkanmaa Hospital District and School of Health Sciences, University of Tampere, Finland.



This was a follow-up of 28 schoolchildren with cows’ milk allergy (CMA) who attended a randomised double-blind placebo-controlled oral immunotherapy (OIT) study. In the original study, 26 (92.9%) completed the six-month escalation phase, and 25 (89.3%) used milk daily at 12 months and 24 (85.7%) at 36 months. This study evaluated the outcome seven years later, with special attention paid to milk consumption and symptoms.


Outcome data were collected through a postal questionnaire completed three, four and five years after enrolment and by a phone questionnaire after seven years. We asked about the daily dose of milk products, any adverse reactions, any medication needed and possible discontinuation of daily milk consumption.


Data were available at the seven-year point for 24 children and 14 (58.3%) of these continued to use milk (≥200 mL) or milk products (protein ≥6400 mg) daily for seven years. However, three (21.4%) of these still reported symptoms associated with milk consumption. Of the 10 remaining children, two children used milk products daily but consumed less due to symptoms and eight (33.3%) had discontinued milk consumption.


Oral immunotherapy was an effective and safe way of desensitising schoolchildren with persistent CMA.

©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

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