Allergist-reported trends in the practice of food allergen oral immunotherapy. 2015

J Allergy Clin Immunol Pract. Author manuscript; available in PMC 2016 Jan 1.
Published in final edited form as:
PMCID: PMC4291536
NIHMSID: NIHMS639581

Allergist-reported trends in the practice of food allergen oral immunotherapy

Matthew J. Greenhawt, MD, MBA, MSc1 and Brian P. Vickery, MD2

Abstract

Food allergen oral immunotherapy (OIT) is an experimental, immune-modifying therapy that may induce clinical desensitization in some patients. OIT is still in early phase clinical research, but some provider may offer OIT as a clinical service. To understand the current practices of allergists performing OIT an on-line survey was emailed to members of the American Academy of Allergy Asthma and Immunology. Among 442 respondents, 61 (13.8%) reported participating in OIT, including 28 in non-academic settings. Informed consent for OIT was obtained by 91.3%, IRB approval by 47.7% and Investigational New Drug (IND) approval by 38.1%. Compared to non-academic participants, more academic participants used peanut OIT, obtained IRB and IND (p <0.0001 respectively), and challenged patients prior to entry (p=0.008). More non-academic providers billed the patient or insurance for reimbursement (p<0.0001). Low reported regard for the importance for FDA approval or a standardized product (increased odds), and high regard for better safety data (decreased odds) were associated with considering to offer OIT as a service. Significant differences exist in OIT occurring in academic vs. non-academic settings. Further assessment is needed regarding the different motivations and practice styles among providers offering OIT, and those considering doing so.

Keywords: Food oral immunotherapy, food allergy, oral food challenge, provider attitudes, sublingual immunotherapy, clinical trial

LINK TO: Allergist-reported trends in the practice of food allergen oral immunotherapy. J Allergy Clin Immunol Pract. 2015 Jan-Feb;3(1):33-8.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4291536/

 

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