Oral immunotherapy for food allergy: towards a new horizon. 2013

Allergy Asthma Immunol Res. 2013 Jan;5(1):3-15. doi: 10.4168/aair.2013.5.1.3. Epub 2012 Nov 28.

Oral immunotherapy for food allergy: towards a new horizon.

Abstract

Food allergy has increased dramatically in prevalence over the past decade in westernized countries, and is now a major public health problem. Unfortunately for patients with food allergy, there is no effective therapy beyond food allergen avoidance, and rapid medical treatment for accidental exposures. Recently, oral immunotherapy (OIT) has been investigated as a treatment for this problem. In this review, we will discuss the progress in developing OIT for food allergy, including a novel approach utilizing Xolair (anti-IgE monoclonal antibody, omalizumab) in combination with OIT. This combination may enhance both the safety and efficacy of oral immunotherapy, and could lead to a widely available and safe therapy for food allergy.

KEYWORDS:

Oral immunotherapy; anti-IgE; desensitization; food allergy; omalizumab; xolair

LINK TO: Oral immunotherapy for food allergy: towards a new horizon. Allergy Asthma Immunol Res. 2013 Jan;5(1):3-15. doi: 10.4168/aair.2013.5.1.3. Epub 2012 Nov 28.

http://www.ncbi.nlm.nih.gov/pubmed/23277873

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