Modulation of dendritic cell innate and adaptive immune functions by oral and sublingual immunotherapy. 2014

Modulation of Dendritic Cell Innate and Adaptive Immune Functions by Oral and Sublingual Immunotherapy

Pamela A. Frischmeyer-Guerrerioa, Corinne A. Keeta, Anthony L. Guerreriob, Kristin L. Chichestera, Anja P. Bienemanc , Robert G. Hamiltonc , Robert A. Wooda, and John T. Schroederc aDivision of Allergy and Immunology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD USA bDivision of Gastroenterology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD USA cDivision of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA

Abstract

Sublingual (SLIT) and oral immunotherapy (OIT) are promising treatments for food allergy, but underlying mechanisms are poorly understood. Dendritic cells (DC) induce and maintain Th2-type allergen-specific T cells, and also regulate innate immunity through their expression of Toll-like receptors (TLRs). We examined how SLIT and OIT influenced DC innate and adaptive immune responses in children with IgE-mediated cow’s milk (CM) allergy. SLIT, but not OIT, decreased TLR-induced IL-6 secretion by myeloid DCs (mDCs). SLIT and OIT altered mDC IL-10 secretion, a potent inhibitor of FcεRI-dependent pro-inflammatory responses. OIT uniquely augmented IFN-α and decreased IL-6 secretion by plasmacytoid DCs (pDCs), which was associated with reduced TLR-induced IL-13 release in pDC-T cell co-cultures. Both SLIT and OIT decreased Th2 cytokine secretion to CM in pDC-T, but not mDC-T, co-cultures. Therefore,

LINK TO: Modulation of dendritic cell innate and adaptive immune functions by oral and sublingual immunotherapy. Clin Immunol. 2014 Nov;155(1):47-59.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252363/pdf/nihms-624659.pdf

 

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