Clinical efficacy and immune regulation with peanut oral immunotherapy. 2009

J Allergy Clin Immunol. 2009 Aug;124(2):292-300, 300.e1-97. doi: 10.1016/j.jaci.2009.05.022. Epub 2009 Jul 3.

Clinical efficacy and immune regulation with peanut oral immunotherapy.

Abstract

BACKGROUND:

Oral immunotherapy (OIT) has been thought to induce clinical desensitization to allergenic foods, but trials coupling the clinical response and immunologic effects of peanut OIT have not been reported.

OBJECTIVE:

The study objective was to investigate the clinical efficacy and immunologic changes associated with OIT.

METHODS:

Children with peanut allergy underwent an OIT protocol including initial day escalation, buildup, and maintenance phases, and then oral food challenge. Clinical response and immunologic changes were evaluated.

RESULTS:

Of 29 subjects who completed the protocol, 27 ingested 3.9 g peanut protein during food challenge. Most symptoms noted during OIT resolved spontaneously or with antihistamines. By 6 months, titrated skin prick tests and activation of basophils significantly declined. Peanut-specific IgE decreased by 12 to 18 months, whereas IgG(4) increased significantly. Serum factors inhibited IgE-peanut complex formation in an IgE-facilitated allergen binding assay. Secretion of IL-10, IL-5, IFN-gamma, and TNF-alpha from PBMCs increased over a period of 6 to 12 months. Peanut-specific forkhead box protein 3 T cells increased until 12 months and decreased thereafter. In addition, T-cell microarrays showed downregulation of genes in apoptotic pathways.

CONCLUSION:

Oral immunotherapy induces clinical desensitization to peanut, with significant longer-term humoral and cellular changes. Microarray data suggest a novel role for apoptosis in OIT.

Note: This study began enrolling patients in March 2007 through December 2008

LINK TO: Clinical efficacy and immune regulation with peanut oral immunotherapy. Journal of Allergy & Clinical Immunology. 124(2):292-300, 300.e1-97, 2009 Aug
http://www.ncbi.nlm.nih.gov/pubmed/19577283

This is the 1st of 3 publications on this study:

See the 2011 study:
https://www.oit101.org/research/a-randomized-controlled-study-of-peanut-oral-immunotherapy-clinical-desensitization-and-modulation-of-the-allergic-response/

 

Clinical efficacy and immune regulation with peanut oral immunotherapy. 2009

See the 2014 followup study which showed sustain unresponsiveness:
https://www.oit101.org/research/sustained-unresponsiveness-to-peanut-in-subjects-who-have-completed-peanut-oral-immunotherapy-2014/

 

Site created by Food Allergy Parents like YOU ! … They said there were NO TREATMENTS for food allergy!